"He opened their minds so they could understand the scriptures" Luke 24:45. Open the mind in the Bible means to receive the 7 spiritual gifts of the Holy Spirit, the integrity, and in this particular case "to understand the scriptures" this refers to the spiritual gift of knowledge. Through the spiritual gift of knowledge we can access to the knowledge of the divine things, the knowledge of the Word of God, the inspire Wisdom.
Is the proper gift of the spiritual man. This passage of the Bible is related with: "The natural man does not accept the things that come from the Spirit of God, for they are foolishness to him, and he cannot understand them, because they are spiritually discerned. The spiritual man make judgements about all things, but he himself is not subject to any man´s judgment" 1 Corinthians 2:14-15
To understand the spiritual gift of knowledge we must know the triple division of man: body, soul and spirit. This triple division give raise to 3 types of man: the natural man (prevails the body), the rational man (prevails the soul) and the spiritual man (prevails the spirit).
The concept of reason explains an intermediate state between good and evil, the concept of reason is related with the natural and rational man, also the faculties of the soul: imagination and fantasy, instead the spiritual gift of knowledge is related with the intuition, the inspiration, the creativity, and the progressive thinking.
The objective of reason are the temporary things instead the objective of the knowledge are the eternal and inmutable things.
http://www.quintoevangelio.com.ar/en/articles/item/238-mind.html